User blog comment:AustinDR/The Worst Theory?/@comment-30126178-20171015232749/@comment-33279747-20171016022559

As I quite thoroughly explained in another blog not long ago, I don't believe any of the Louds were written with any specific disorders in mind, and any resemblance to a real-life mental or neurodevelopmental disorder are purely accidental. But we all know that people are going to "diagnose" these characters anyway, so here goes.

I don't think we have enough information to go on for Luan. She may exhibit one or two strong signs of Asperger's but not at all in others (such as deficits in social skills and non-verbal communication). Lisa is too young to make that call just yet - all of her behaviors and obsessions could point to many very different mental conditions at this point. We'd have to wait and see how she develops over the next decade of her life (but of course, cartoon characaters have a habit of not aging). The theory of Leni having ADHD doesn't carry much weight at the moment, at least not any more than the autism theory. I don't believe she has either of these.