Lincoln enters the living room, and is surprised to see that it is empty. He then walks towards the kitchen, only to find Luna guarding the entrance. She tells him that Lori is in the kitchen cooling off after a fight she had with Leni, and won't let him in. Lincoln insists on going in, as he's hungry, but Lisa tells him that she found something under the sofa cushions. She hands him a bagel, but as Lincoln takes a bite of it, she informs him that it is covered in lint, dog hair, and a booger. He runs upstairs, only to find Lana guarding the bathroom. She tells him that Leni is in the bathroom cooling off, and that he can use a bucket to throw up in, which he reluctantly agrees to.
Later on, he wants to watch a Monster Truck Rally on TV, but Lynn, Lucy, and Lola won't let him, as it would only provoke Lori and Leni. Lincoln asks what their fight is about, and they finally tell him why: yesterday, they both bought the same dress, and are angry at each other when one refuses to return theirs. Lincoln is flabbergasted at the two of them fighting over such a petty thing, but his sisters tell him that it's "a sister thing," for which they have a sister protocol, meaning that he should stay out of it, so they can resolve it on their own.
Lincoln can no longer stand what Lori and Leni's fighting is causing, so he decides to try and help them make peace with each other. He goes into their room, only for them to be sitting there perfectly fine, and they both try to tell him that he doesn't need to try and help them resolve it, as it's already been resolved. Unfortunately, he doesn't listen, and causes them to fight again when he reveals what they both say about each other behind their backs. This makes Lori and Leni even angrier at each other, resulting in making the fight even worse. Lisa, saying that the threat has increased, commands the other sisters to get themselves ready, with Lola telling Lincoln to let them handle it. Later on, Lincoln's room is being used to allow either Lori or Leni to temporarily house them, while the other passes by the upstairs hall. At dinner, Rita and Lynn Sr., who are revealed to follow the protocol, says that they have dinner with Lori and Leni separately, so that way, they won't appear to be taking sides. Things get even worse when Lincoln's bed sheets and blanket are gone, so that they can be used as a wall to divide in between Lori and Leni. Lincoln tries to help settle this again, which only worries the other sisters, and they try to tell him to just allow Sister Fight Protocol to settle this. But Lincoln, fed up with the protocol, insists that Leni sleep in Luna and Luan's room, while Luna sleeps in Lori and Leni's room for the night. They agree to this, but the other sisters (including Lily) protest against his idea. However, Lincoln insists that this will be sorted out in the morning.
The following morning, Lincoln awakens to thinking that everything is back to normal, only to hear Luna and Luan fighting. They both argue over whether it was Lori or Leni who had the right to be mad at the other, and it leads to them insulting each other. Now the protocol has to be used to separate the two of them, and once again, Lincoln's room is used as a spot to temporarily house one of them. Lisa tells Lincoln that the fight has escalated even worse on her chart, and this causes Lynn Sr. to panic, as he and Rita lock themselves in their room with Lily.
They continue with their protocol of keeping the fighting siblings separate from each other, but when Lola and Lana accidentally cross paths with Luna and Luan, this causes them to start fighting as well. Bobby comes by to deliver pizzas to the family, but he delivers one to their parents through their bedroom window, and they advise him to leave the rest on the porch, and run off, as soon as he rings the doorbell. Later on, Lynn is eating pizza, while Lucy chastises her for slacking on the job, and this leads to the two of them also getting into an argument. Lisa is now frightened, as the chart is at the highest level of disaster, and Lana angrily bites into it, which causes Lisa to start fighting as well. At this point, every one of the sisters (except for Lily) are arguing, and Lincoln, realizing the severity of the situation, calls up Clyde, and asks if he can visit, and Clyde accepts.
Later on, Lincoln is at Clyde's house, explaining his dilemma, and Clyde is listening to him, as if he were a therapist. Lincoln explains that the sister fight protocol is ridiculous, and only makes everything worse, and says that if they allowed him to help, he would’ve resolve things. After explaining, Lincoln says that tomorrow morning, he's going back to the house, and attempt to resolve everyone's issues.
The following morning, Lincoln returns home to try and fix the problem, but everything is quiet. He opens the front door, and find his sisters sitting peacefully in the living room. They explain that they resolved everything themselves, thanks to him leaving since he wasn't there to butt in, proving that their sister fight protocol works. He finally agrees to this, but, unfortunately, thanks to his honest truth, he reveals more things that the sisters say behind each other's backs (Lynn saying that she can't stand Lisa's spitting when she talks and Lana saying that Lola' snoring bothers her), causing them to fight once again. When Lynn Sr. comes out of his bedroom, thinking it's over, every one of the sisters begin fighting yet again, and this time, Lincoln hides with his parents in their bedroom, to avoid the sisters' brutality.
Every Loud sister gets in a fight with their roommate, except Lisa who got in a fight with Lana instead of Lily. In addition, Lily is the only sister who was not involved in any fights, except for the ending.
A storyboard image featuring Luan getting angry at Lincoln from this episode was present long before it even aired and even before this episode was announced.
All the fights of the sisters and the reasons why they fight:
Lori and Leni: Bought the same dress.
Luna and Luan: How Lori and Leni got the dress.
Lana and Lola (1/2): Stepping into each other's zones.
Lynn and Lucy: The former eating pizza.
Lana and Lisa: The former destroys the latter's chart.
Everybody (1/2): They argue and attack each other.
Lynn and Lisa: Lincoln's secret of Lynn saying she needs a windshield wiper every time Lisa talks.
Lana and Lola (2/2): Lincoln's secret of Lana saying Lola snores likes Pop-Pop.
Everybody (2/2): Lincoln's big mouth (wasn't true since he only spoke on Lisa and Lola).
Irony: Everybody was informed about the sister fighting protocol, even Lily (the baby) and Bobby (non-Loud) but not Lincoln.
Brawl in the Family - The title of this episode is a parody of the 1970s sitcom All in the Family.
Eau de Death - When Lucy told Lynn she smelled like crusty athletic socks she responded with saying "oh, like Eau de Death is better" which references this scientifically made cologne of the same name that is meant to make you smell like the undead.
Back to the Future Part II - The sports almanac Lynn is reading "by Biff" resembles the one from the movie, which is stolen by a bully named Biff Tannen, so he can travel back in time, and get rich by betting on sporting events he already knows the outcome of.
Lana had some toilet paper stuck to her foot while she was talking to Lincoln about his bedsheets. Later, when she was waking up the others, the toilet paper was missing.
It is revealed that there's a sister fight protocol when two sisters get into a fight. However, no such protocol is featured in the episode when a similar incident happened when Lynn and Lucy fight with each other during the events of "Space Invader".
When Lori and Leni start arguing after Lincoln's first attempt to end their fight, their lip movements do not match what they're saying.
At the end of the episode, Lincoln triggered Lisa and Lola into arguing, so it is unknown why the remaining sisters began arguing as well.
In that same scene, Lisa was arguing with Lynn, but when the remaining sisters were seen arguing, Lisa was seen arguing with Luna, while Lynn was arguing with Luan.
When Lynn, Lucy, and Lola attack Lincoln to prevent him from grabbing the TV remote, Lana's cap can be seen in the smoke cloud, despite her not being present.
When Leni says "Well, I'm not sleeping with her!", the eyelashes on her right eye are missing.
When Lincoln is about to enter the house near the end of the episode, he has a trash can lid for a shield, but when he opens the door, he doesn't have it anymore.
At the dinner scene, when the family is switching their mostly eaten plates of spaghetti for some fresh new plates, Lynn Sr. has a tray under his plate. However, the tray is not seen in other shots of said scene.
When Lisa spits in Lynn's face, Lynn's eyelashes are missing.
When Lori was arguing with Leni about Lincoln saying that she said she looks like Aunt Ruth, her eyelashes were missing.
When Lincoln notices his bedspread missing, he mentions both his sheets and blanket, but when he takes them back, only his blanket can be seen.
When Lincoln leaves Lori and Leni's room in the beginning of the episode, the stairs were missing.
One of the rules of the Sister Fight Protocol is to stay out of the argument, but Luna and Luan broke that rule when they were arguing whether Lori and Leni had possession of the dress first.
In the Italian dub, Lincoln's line when he sees that his sisters are not fighting anymore ("What's going on? What happened to the fighting?") is missing the "to the fighting" part, leaving a brief scene where his mouth is moving but nothing comes out.