The series' protagonist, an 11-year-old boy who is the middle child and only son in his family. He is known for making creative plans around his sisters' antics to get through the day and achieve his goals. He is usually seen reading comic books and playing video games.
The oldest sister in the family. She is 17-years-old, and while sometimes overbearing and cruel, is truly a caring sister, and leader at heart. She often leads sibling meetings and, spends most of her time on her phone with her friends, especially her boyfriend, Bobby Santiago.
The second-oldest sister in the family. She is 16-years-old, and although she may not be very bright, she is very kind-hearted. However, she does possess a vast knowledge of fashion designing and can turn nearly any piece of fabric into clothing. She can also easily pick locks.
The third-oldest sister in the family. She is 15-years-old, a free-spirited and caring musician, with a great passion for rock and roll music. She plays different instruments, but mainly her electric guitar, which she refers to as her "axe".
The fourth-oldest sister in the family. She is a fun-loving, goofy 14-year-old comedienne and prankster. On April 1st, she sets up pranks around the house, making her siblings want to stay in their rooms. However, Luan has her methods of luring them out.
The fifth-oldest sister in the family. She is an athletic 13-year-old tomboy who participates in various types of sports, is very competitive, and superstitious. She is always determined to be number one.
The fifth-youngest sister in the family. Lucy is an 8-year-old goth girl with a tendency to suddenly appear out of nowhere, which often frightens her siblings. Still, she has amazing poetry skills and never fails to ask her siblings for rhymes of words.
The fourth-youngest in the family, 6-years-old, and the older of the family's two twin girls. Lana is a tomboy who loves to play in mud, much to her twin Lola's annoyance. She's also very well experienced with tools and has numerous exotic pets.
The third-youngest sister in the family, 6-years-old, and Lana's polar-opposite identical twin sister. Lola is a conceited and occasionally bratty girl, who often assumes the role of an antagonist whenever her siblings anger her.
The second-youngest sister in the family who, despite being only 4-years-old, is very smart and gifted. She enjoys different experiments, and also using her siblings as test subjects. She also invades their privacy such as installing cameras in the bathroom.
The youngest sister in the family. She is only 15-months-old, and her diaper has a foul smell, which she takes off mostly. Lily rarely cries, and she is often seen as very happy and bubbly in the Loud House.
The Loud siblings' father, who works as a chef as of "Job Insecurity" and owns a restaurant as of "Cooked!". His kids have inherited numerous traits from him, such as Luna, with their love of music, Luan, with their sense of humor, and Lynn with their love of sports.
The Loud siblings' mother, who works as a dental assistant as revealed in "A Novel Idea". She is more mature than her husband, but is very affectionate and loving towards her children, and supports them no matter what.
Howard and Harold McBride are Clyde's dads. Howard is the neurotic and overemotional one with buck teeth, and Harold is the calm and athletic one. They both show a lot of protection and care towards Clyde.
Bud Grouse is the Loud's next door neighbor. He often calls out to the Louds, and says "Hey Loud", and then says something random. Lynn Sr. claims he is just "an old coot with a bad lasagna addiction."
Hector Casagrande is Rosa's husband and the owner of the family's bodega, which he plans to let Bobby take over when he retires. He enjoys gossiping with his customers and serenading his family with his guitar.
Rosa Casagrande is Hector's wife and the resident cook of the Casagrande family. While she is always happy to cook for her family, she tends to go overboard. She keeps many scented candles, lucky talismans, potions and health remedies.
Carlos Casagrande is Maria's older brother, Frida's husband and the father of Carlota, CJ, Carl and Carlitos. He is bibliophilic and an absent-minded college professor who often states facts he reads from books.
Frida Puga Casagrande is Carlos' wife, and the mother of Carlota, CJ, Carl and Carlitos. She loves to take pictures for just about every family moment, but tends to be very emotional and is moved to tears very easily. She also has a talent for painting.
Carlino Casagrande, often known as Carl, is the second youngest of the Casagrande siblings. He enjoys feeling like a boss and can be a bit of a show off sometimes, especially to Lori, who he has a huge crush on and will often try to upstage Bobby for her.