At school, Mrs. Johnson informs her students that the last thing they'll be doing for their biology course will be dissecting frogs. All of her classmates are intrigued by this, especially Lincoln. However, Lana gets word of this activity, and strongly objects to it. To show Lincoln why he shouldn't dissect frogs, Lana shows him a video she made about how she and her pet frog, Hops, met. While playing in a lake, Lana enjoyed playing with a frog, but when she began to leave, the frog became depressed. Seeing the frog so depressed, Lana offers to take him home with her (which he agreed to), and later names him Hops. Ever since that day, Lana and Hops became virtually inseparable. The video leaves Lincoln in tears, and agrees to not dissect frogs. Now convinced why he shouldn't dissect frogs, he suggests to Lana that they go on a rescue mission to help the frogs that are soon to be dissected.
Back at school, it's time for lunch, and when the students leave, Mrs. Johnson locks the classroom door. When Lana's lock-picking tactic doesn't work, she and Lincoln resort to climbing through the air vents. After nearly exposing themselves to Principal Huggins, Lincoln and Lana manage to find their way into Mrs. Johnson's classroom. However, before they can escape with the frogs, Mrs. Johnson returns, and to her horror, realizes the frogs are gone. When she sees the classroom window wide open, she assumes that the frogs escaped, and runs out the classroom, as she goes to alert Principal Huggins. In actuality, Lincoln and Lana hid underneath the desk, and used the window as a diversion. With her gone, Lincoln and Lana sneak the frogs out of the school.
Lincoln and Lana bring the frogs to a lake and let them out of their cage, but it almost immediately becomes apparent to the siblings that the frogs they just rescued don't know how to survive in the wild. Because of this, and the factor that numerous predators want to eat them, they're forced to make them take shelter at the house. After bringing the frogs to the house, Lincoln and Lana head back to school due to lunch break ending. At school, Principal Huggins informs the students that the frogs are missing, and comes to conclusion that someone set them free. Because of this, he'll be searching each one of the students' houses after school to see if they're sheltering the frogs.
Lincoln and Lana arrive back home, but to their dissatisfaction, all the frogs are on the loose. To make matters worse, Principal Huggins arrives to inspect the house. As he begins to inspect the house to find the frogs, Lincoln and Lana continuously distract him when he gets close to a frog's hiding place. After searching the first floor, Principal Huggins proceeds to search the second floor. After finding nothing, Principal Huggins concludes that there are no frogs around. However, when he grabs his coat, a bunch of frogs jump out of it, since Lincoln and Lana were using his coat to cover up some frogs. With the big secret out, Lincoln and Lana apologize to the frogs, and wish there was a way to show why frogs are cool. Hops then pulls out the video reel Lincoln looked at earlier, and decides to use that to convince Principal Huggins why the frogs shouldn't be dissected.
Back at the school, Principal Huggins, along with Mrs. Johnson, are left tearing up after seeing the video about Lana and Hops. As a result, Principal Huggins decides not to let the frogs be dissected. However, because of this, nobody knows what to do with the frogs. Lincoln suggests on making a habitat for the frogs for the classroom, which leaves the students impressed.
As Lincoln and Lana head home from school, it's revealed that Lincoln (and presumably Lana) ultimately ended up getting a detention for setting the frogs free in the first place--Lana, feeling guilty, apologizes to Lincoln for what happened. However, Lincoln assures her that he's fine with it, since he knows that the frogs are safe. Suddenly, he and Lana pass by Jean Juan's French Mex and noticed the special they're serving: roasted duck enchiladas. Shocked, the brother and sister run off carrying several boxes of ducks, leading to another rescue mission yet again.