There's a powerup in the game called "Gas Mask". Putting on the gas mask will make Lincoln be able to get closer to the germs, but it only lasts for a few seconds.
When Lincoln's spray can is low on spray fuel, he can collect the Spray Refills to refill his spray can.
The Bug Bomb can destroy all germs in all areas that Lincoln is in, but Lisa tells Lincoln that he doesn't want to be near it when it explodes, so move Lincoln away from the Bug Bomb as fast as you can!
The four messages that can show if you lose the game are "Sneezy diseasey", "You're snot looking too good!", "Your new name is Germy McGermface", and "Welcome to bed-and-barf town. Population: you!".
It is unknown where Lincoln and Lisa's sisters, parents, and pets are during the game.