This page describes all of Lisa Loud's relationships with her family and friends.
She often looks and talks down to her siblings, due to her prodigy intelligence. She likes to use them as test subjects for her experiments, much to their fear. She loves her family, but otherwise is all think, and no feel, even against the gothic Lucy, because of this, she doesn't seem to have much of a connection with anyone, but is always available to help them with any problem, such as tutoring.
In Last Loud on Earth, they all tell her the password is her birthday.
Lincoln has a fear of messing up one of Lisa's experiments, or breaking her stuff and making her angry, or upset at him. Despite this, Lisa and Lincoln get along pretty well.
In the pilot, he reminds her to carry a one in her equation.
In "Left in the Dark", Lisa asks Lincoln for groceries, and he gives them to her.
In "Heavy Meddle", she easily finds out about Lincoln's secret that he's being picked on at school. She states that she does not have enough room in her brain for keeping it to herself and tells it to Lynn, who in turn tells the other sisters, much to his chagrin. Though this is likely out of concern for the well-being of their only brother.
In "Making the Case", she writes a note while pretending to disown him by saying "Vengeance shall be mine" which quickly drops. Later she hugs him to show their even.
In "No Guts, No Glori", he lets her do experiments while in charge, however, this backfired when she created life. She then used her invention to help him and Lori clean up.
In "The Sweet Spot", a flashback reveals that Lincoln gets annoyed when Lisa won't shut up about dangers of car travel. She even corrected him why sweet spot gets its name.
In A Tale of Two Tables, she rubs ketchup off his face and hits him with mashed potatoes.
In "Project Loud House", he gets annoyed with her experimenting on Leni and demands that she give him the antidote.
In "In Tents Debate", she tries to convince him to pick Dairyland as the vacation spot by helping Lynn, Luna, Luan, and Lana clean his room and give him a pretend ride. She's also the one who comes up with the idea of "Team Tippy" waiting on Lincoln, and gives him a massage (along with Luna and Luan). When the girls in favour of Dairyland try to convince Lincoln that Aloha Beach is worse, Lisa contributes by handing him sodium hydrochlorite to simulate a sunburn.
In "Picture Perfect", Lincoln swaps Lisa's glasses for Leni's shades because he thinks those look better on her. However, Lisa falls down the stairs and gets a hairline fracture.
In "Linc or Swim", Lincoln becomes concerned when Lisa puts something in the pool, but she informs him that she's only disinfecting it.
In "Overnight Success", Lincoln is annoyed at Lisa for stealing time away from hanging out with Clyde by experimenting on him.
In "Sleuth or Consequences", he and Lucy wonder if Lisa clogged the toilet, or knows who did so. However, she did not know, and she informed them that she prefers using the training potty over the proper toilet.
In "Butterfly Effect", Lincoln breaks Lisa's chemical bottles with his yo-yo and he fearfully believes Lisa will get mad for what he did, but instead of being angry, Lisa becomes ecstatic with Lincoln. She hugs him and thanks him for proving her hypothesis and for admitting what he did. She even jokes about his fantasy.
In "The Green House", he tells her to convert Lily's dirty diapers into electricity instead of using the mains. She is pleased with this idea despite disliking the smell and calls him a genius. Later, she and rest of their sister scold Lincoln for being a hypocrite and goes back to using the mains.
In "Along Came a Sister", Lisa helps Lincoln protect Frances the spider by washing out the exterminator's mouth with ghost pepper-flavoured mouthwash.
In "For Bros About to Rock", Lisa tells Lincoln about the time Luna spoiled her opera concert.
In "Attention Deficit", Lisa, like all his sisters, prevents Lincoln from getting attention. In her case, she did experiments, which required assistance.
In "Cereal Offender", Lincoln gets annoyed when Lisa lies in the freezer to practice cryogenics.
In "Lincoln Loud: Girl Guru", he gives the other boys advice to learn basic chemistry to impress girls, inspired by Lisa telling a boy in her class to "learn basic chemistry, then we'll talk". She even laughs when he explains.
In "Roughin' It", Lincoln learns how to navigate using tree moss from Lisa.
In "Raw Deal", Lisa tries rather unsuccessfully to warn Lincoln that nothing bad will happen to him on his trip to the park. He then uses Lisa's not having made a discovery as proof that he will be fine.
In "One of the Boys", he dreams that she gives him a portal into a universe where he has ten brothers instead of ten sisters.
In "Snow Bored", Lincoln tries to teach Lisa to toboggan and build an igloo, but she does not like it. Later, she drops snow on him and Leni.
In "One Flu Over the Loud House", she is the one who tells Lincoln that the house is infected with flu.
Lincoln is very disgusted when Lisa uses her family as lab rats and performs experiments on them without their knowledge. He angrily yelled at her when she experimented on Leni in "Project Loud House" and Lily in "Changing the Baby".
In "Baby Steps", it was shown that Lisa enjoys the peanut butter and jelly sandwiches Lincoln makes for her.
In "Brawl in the Family", she keeps saying Lincoln makes things worse. Later she tells him he did the right thing by leaving. Lincoln claims that Lynn hates Lisa's spitting when she speaks.
In "Making the Grade", Lisa gets promoted from kindergarten to the fifth grade after finding kindergarten too easy. Her intelligence makes Lincoln an outcast and he tells Lisa to tone it down. Then Lisa's new personality made her become relatively popular. However, this causes issues at home because Lisa cannot help her family solve things that the others cannot and their other sisters (except for Lily) take their anger out on Lincoln.
In "The Whole Picture", it was revealed Lincoln used to feed her with milk.
In "No Such Luck", she initially disbelieves his lie about being bad luck, but he manages to convince her by breaking Lori's golf club.
In "Shell Shock", Lincoln tries to keep his egg "baby" safe from Ronnie Anne by sitting with Lisa, which she thought was unwise because of her rambunctious classmates.
In "Pulp Friction", Lincoln bases his superhero the Card Counter upon Lisa.
In "Room with a Feud", his quiz determines that she and Luna would make ideal roommates. When that doesn't work out, she claims that the quiz is asinine. Later she admitted him bunking with lily was a blunder.
In "Garage Banned", it is revealed by Lori that Lisa took Lincoln's appendix while she was trying to take one of his kidneys.
In "Yes Man", Lincoln tells Lisa to use her talents to convince Rita and Lynn Sr. to give her money. When this works, he later tries doing the same thing Lisa did, but it doesn't work because they have no money left.
In "Friend or Faux?", she observes him and Clyde as part of her study on friendship.
In "Mall of Duty", he tries to keep her and his other younger sisters entertained by playing I Spy, but she finds it boring. Later, when Lisa goes missing, he finds her by noticing acid on the floor.
In "White Hare", Lisa tells Lincoln that he is smart.
In "A Fridge Too Far", Lincoln and Lisa came up with an idea to satisfy their sisters in maintaining their leftovers by using a color coded compartment system in order to know where their leftovers are. Afterwards, Lisa asks Lincoln for one of his Mac 'n' Cheese bites, but Lincoln refuses.
In "The Mad Scientist", Lincoln packs peanut butter and jelly in her bags, in case she misses it.
In "Predict Ability", Lincoln's fears that he was predictable began when Lisa pointed out that he peed at 7:03 every morning. Later, when he's first to go to the bathroom instead, she thought her clock was wrong, but he told her he was just going first for a change.
In "Kings of the Con", Lisa helps to save Lincoln (and Clyde) by throwing her abacus at Kitty.
In Last Loud on Earth, she demands how he got in.
In Living Loud: Lincoln's List, he makes her some warm milk.
In Living Loud: Summer School, she helps him get straight A's.
In Germ Squirmish, she helps him disinfect the house.
In Listen Out Loud, Lisa's episode has Lincoln pretend to be a grown man so that he can ask Lisa which video game he should play to win ten tickets. He also describes her as "single-handedly supporting an entire ecosystem".
Lisa and Lori don't have a lot of interaction, although Lori already knows about Lisa's strange experiments. She hates Lisa's poop study as shown in "Undie Pressure", and doesn't like that she uses her siblings as "guinea pigs" as shown in "Left in the Dark".
In "Driving Miss Hazy", Lisa does Lori's math homework in exchange for driving her to the planetarium.
In "Snow Bored", Lisa snowballs Lori while the latter is talking to Bobby.
In "Study Muffin", it revealed that Lisa tutors Lori for pre-Calculus and tells her to move it or lose when Lori is three minutes late.
In "Garage Banned", Lincoln goes to Lori for help when Lisa tries to take his kidney. Lisa says to Lori, "Tell Lincoln he only requires one!". Lisa also annoyed Lori by going into her and Leni's room while Lori was on the phone and claiming she could check Lynn's brain.
In "No Place Like Homeschool", Lori thinks Lisa is missing the point when she goofs off by studying a different subject than the ones she's supposed to study.
In "The Mad Scientist", Lori reads Lisa and Lily a bedtime story.
In "Can't Hardly Wait" to assist Lori in taking orders at Lynn's Table, Lisa invents a backpack with robotic arms. Unfortunately, the invention goes haywire, forcing Lori to rip it's arms off to shut it down.
In Living Loud: Surprise Party, Lisa helps set up the picnic for Lori's birthday party.
In Dairyland Amoosement Park (game), Lisa uses green powder to photo-bomb Lori and Bobby.
In Welcome to the Loud House, Lisa is the only sibling to do absolutely nothing when handed Lori's phone.
In "Left in the Dark", Lisa experiments on Leni, leaving Leni with a swollen, blotchy face.
In "Project Loud House", Lisa swaps Leni's acne cream with something that makes her skin change colour. Lincoln insists Lisa give Leni the antidote and she does, but not before trying to test something else on Leni.
In "Picture Perfect", Lincoln swaps Leni's shades and Lisa's glasses. Leni then falls down the stairs and lands on Lisa, leaving Leni uninjured but Lisa with a break in an unknown place, exacerbated because she already had a hairline fracture there.
In "Attention Deficit", Leni mistakes the McBrides' grandfather clock for Lisa's room.
In "Snow Bored", Lisa drops snow on Leni and Lincoln through the chimney. Lisa also gets annoyed with everyone copying Leni's "F-O-N" chant.
In "The Mad Scientist", Leni zips Lisa's sleepwear on.
In "Slice of Life", when Lisa suggests using calipers, Leni doesn't understand and presumes Lisa said caterpillars.
In Thanksgiving Seating Arrangement Trouble, Lisa teaches Leni how to use a knife and fork.
In Lights Out, Leni eats one of Lisa's Gloweo cookies.
In Welcome to the Loud House, Lisa doesn't like Leni's driving outfit.
Given their complete opposite IQ levels, Leni's absent-mindedness tends to get on Lisa's nerves at times.
Lisa and Luna don't have a lot of interactions between them, but they do get along with each other and have an explosive personality.
However, in "The Sweet Spot", it is revealed that Luna's singing annoys Lisa, because it gives her tinnitus.
In "In Tents Debate", they both vote for Dairyland over Aloha Beach and try to get Lincoln to select their side.
Also, in "For Bros About to Rock", it is revealed that Luna ruined her first opera, by jumping off the stage and landing on the orchestra, in an attempt to stage dive.
Lisa also refused to provide Luna shelter in "April Fools Rules", stating that Luna should have been more prepared.
In "Making the Grade", Luna asks Lisa to help study for a test but is unable to help due to her being average thanks to Lincoln, which causes Luna to give him the death stare.
In "Room with a Feud", Luna and Lisa become roommates after taking a compatibility test. At first, they seem to work out fine until Luna disobeys Lisa's orders not to play any note above a D6 which broke her beakers and her glasses.
In "Roadie to Nowhere", Lisa gives Luna some advice about her future. At the end of the episode, Lisa is shown with the rest of their family cheering for Luna at the Royal Rumble.
In "The Mad Scientist", Luna refers to Lisa as being "cold as ice" upon learning that the younger sister cares more about science than her own family. Lisa isn't the least fazed by that statement.
In "House of Lies", Luna tells Lisa that she cannot just force their family to tell the truth all day, but Lisa disagrees with Luna's statement.
In "Really Loud Music" Lisa gives Luna some advice when Luna keeps hearing songs.
In the comic "Sam's Pick", it is confirmed that Lisa, along with the rest of her siblings, is aware that Luna's crush, Sam Sharp, is a girl. This shows that, in spite of her scientific nature, she is very open-minded and still cares for Luna no matter her sexual orientation.
She and Lisa don't have too much interaction, but they do get along with each other. Like all her siblings she gets annoyed by Luan's (mostly) unfunny jokes, and Luan doesn't like Lisa using her as a test subject.
In "Left in the Dark", Lisa uses her to prove her "Gloweos" cookie, resulting in Luan's entire body glowing.
In "Cover Girls", Lisa dresses up as Luan at one point.
In "Funny Business", it's revealed that Luan made Lisa her assistant, but she failed.
In "Snow Bored", Luan tries to teach Lisa how to pull pranks in the snow.
In "Fool's Paradise", Luan pranks Lisa by trapping her in a fold-out bed. Lisa could have gotten out, but she decided to stay there because she thought it was safer.
In "Garage Banned", Luan shows Lisa her medical humor.
In "Future Tense", Luan and Lisa go together to get people to vote.
In "No Laughing Matter", Luan throws a pie at Lisa's face and makes a pun on the words "pi" and "pie". Then, later, Lisa thinks Luan is going to throw cake at her, but she doesn't. She tries to get Luan to tell jokes again using time travel, but everybody declines upon hearing that it may cause their butts to end up in front.
In "Fool Me Twice", Lisa passes out after Luan makes her stunt double claim that discovering what noise a cat makes is a scientific breakthrough.
In "A Pimple Plan", Lisa tries to zap Luan's pimple off but zaps her scrunchie off instead.
In Luan's episode of Listen Out Loud, she pranks Lisa by strapping a jet pack to her chair. In Lisa's episode, Luan asks Lisa a math question regarding balloon animals and, during her apology, describes Lisa as "super-intelligent".
In Welcome to the Loud House, Luan plays a prank that involves some liquid from Lisa's beakers.
She and Lisa don't have too much interaction, but they do get along with each other. In "Butterfly Effect", it is revealed that Lisa tutors Lynn for her exams to let her stay in her sport teams.
In "Heavy Meddle", when Lisa couldn't store Lincoln's secret that he was being picked on at school in her brain, she told Lynn who told everyone else and claimed Lynn's brain had plenty of room. Lynn thought it was a compliment at first, but then realized what her genius sister meant.
In "Cover Girls", Lynn dresses up as Lisa.
In "Snow Bored", Lynn tried to teach Lisa how to bobsled, but Lisa gave up after crashing.
In the ending of "Brawl in the Family", Lincoln revealed that Lynn stated she would need a windshield wiper every time Lisa would speak. This increased Lisa's temper toward Lynn as she angrily asked the latter what she said while spitting over Lynn's face.
In "Lynner Takes All", after they finish a game of "The Settlers of Cat-Land" with everyone tied for first except for Lynn who finished in second, she angrily demands her to recount the score. Unintimidated, Lisa smugly states that she does not make errors. Later, when they agree to play again, Lisa bangs the table hard enough with her fist to make the die Lynn rolled switch from one to six.
In "Friend or Faux?", Lisa studies Lynn and Margo during her study of friendship.
In "The Mad Scientist", Lisa is annoyed by Lynn farting and saying, "Boom!".
In "Sitting Bull", Lynn gives Lisa a noogie.
In Living Loud: Summer School, Lisa finds out about Lynn's habit of putting things on flagpoles, but doesn't want to reveal how.
In Lisa's Listen Out Loud episode, Lynn asks Lisa about baseball. She then runs out in the middle of her game to apologise to Lisa, jokingly hits her literally when Lisa says, "Hit me.", and describes her as "awesome".
They don't have much interactions but they argue about their science and magic. Lisa questions scientific possibility of Lucy's fortune telling in "Raw Deal". However, they can cooperate if necessary as seen in "Come Sale Away".
Like all of her siblings, Lisa doesn't like Lucy appearing out of nowhere, while Lucy doesn't like Lisa using her as a test subject.
In "A Tale of Two Tables", they both sat at the kiddy table.
In "Sleuth or Consequences", Lucy steals some of Lisa's files to cover up for the fact that she clogged the toilet.
In "Cover Girls", Lisa briefly wears a wig that looks like Lucy's hair.
In "Come Sale Away", Lisa and Lucy look for Lily's blanket together.
In "Raw Deal", Lisa expresses doubt about Lucy's fortune cards.
In "Snow Bored", Lucy shows Lisa about having fun on a snow day by lying in the snow.
In "One Flu Over the Loud House", Lucy sneezed on Lisa and she gets sick.
In "Study Muffin", Lisa tutors Lucy for math.
In "Spell It Out", Lucy gets angry at Lisa for spilling her potions on her books and tries to enchant her with a spell.
In "Job Insecurity", when Lisa says she put a tracking chip on their Dad, Lucy asks her if she put it on her and the rest of the siblings, and Lisa lies by saying no.
In "No Spoilers", Lucy asks Lisa about how she came up with inviting Flip, Mr. Grouse, and Dr. Feinstein and that just because their Mom encounters them does not mean she likes them. Lisa responds to Lucy just because their mom uses toilet paper doesn't mean she'll find it a suitable party decoration.
In "Tricked!", Lucy complemented Lisa for making excellent fake blood, but suggested to add some molasses for better consistency.
In "A Fridge Too Far", they are shown sitting next to each other in the living room table before and after Lincoln accuses his sisters of stealing his food. Later, Lisa mistakes her Dad's beets for Lucy's homemade blood.
In "The Mad Scientist", Lisa celebrates not having Lucy around when she goes to the institute.
In "No Place Like Homeschool", when Lisa suggests she and the siblings should find a quiet environment to study, Lucy says she and the other siblings won't fit in her coffin, and Lisa says they should choose an alternative idea. Inside Lisa's bunker, she and Lucy sit next to each other on the top bunk bed.
In "Head Poet's Anxiety", Lisa checks Lucy's vitals.
In Welcome to the Loud House, Lucy spills Lisa's potions.
They don't have many interactions, but they do get along well with each other.
In "A Tale of Two Tables", they both sat at the kiddy table.
In "In Tents Debate", they both want to go to Dairyland and try to get Lincoln to vote for it.
In "Cover Girls", Lisa briefly wears overalls that look similar to Lana's.
In "Snow Bored", Lisa destroys Lana's snowman and snowballs her in the bathroom.
In "Brawl in the Family", Lisa gets mad at Lana for taking a large bite out of her chart.
In "Garage Banned", when Lynn tells Lucy she needs her brain checked, Lisa volunteers to actually check Lucy's brain.
In "Mall of Duty", they can be seen playing cards at the beginning and end of the episode.
In "The Mad Scientist", Lana, along with Lincoln, question her if they should eat a moldy cupcake which they found behind the radiator.
She and Lola interact quite a bit, though their relationship is hit and miss considering the circumstances.
In "A Tale of Two Tables", they both sat at the kiddy table. Lola laughs at Lisa getting hit by Lana's peas, though this was by accident.
In "A Tattler's Tale", Lola blackmails Lisa into doing her homework for her.
In "Snow Bored", Lola tries to get Lisa to try figure skating only for Lisa to calculate Lola's weight breaking through the ice.
In "Study Muffin", Lisa tutors Lola for biology.
In "11 Louds a Leapin'", Lisa continuously tells Lola that she has no chance of getting on Santa's nice list.
In "Baby Steps", they were heard arguing.
In "Suite and Sour", they act out the business center scene in their play to beg their parents to take them and the rest of the kids to the spa with them.
In "Making the Grade", Lola wants Lisa to give the answer to a radio contest, but Lisa botches it after giving up her smarts.
In "Out of the Picture", Lisa takes her x-ray instead of a picture for the yearbook.
In "Garage Banned", Lisa creates a serum that sprays and cuts off Lola's hair, leaving her bald and enraged.
In Welcome to the Loud House, Lisa studies Lola's flowers.
Lisa has a good friendship with her, as both of them have to share a room. In "Changing the Baby", Lisa tries to use Lily on an experiment that appears to be very dangerous. She also tries to implement her interests on Lily, because she has no one else whom shares the same interests as her.
In "A Tale of Two Tables", they both sat at the kiddy table.
In "The Green House", Lisa converts Lily's used diapers into electricity.
In "Ties That Bind", Lisa carried Lily into the direction of the bathroom.
In "Brawl in the Family", Lisa and Lily are the only roommates that do not get into a fight.
In "Party Down", Lisa and Lily are seen playing with the chocolate fountain together.
In "Potty Mouth", Lisa accidentally swears in front of Lily.
In "Tricked!", Lisa and Lily dress up in matching costumes and work together when they went trick-or-treating. The kangaroo costume Lisa made was built so that it can carry around Lily in her joey costume.
In "Any Given Sundae", Lisa mistakes Lily's calling a meeting for her needing to be burped. Later, she wonders if Lily orchestrated getting her first sundae.
In "Geriantics", Lily is annoyed by Lisa waking her up at night.
In Living Loud: Summer School, Lisa accidentally gives Lily coffee.
In Living Loud: Surprise Party, Lisa watches Lily while setting up the picnic blanket.
Unlike most of her siblings, Lisa doesn't interact much with her parents, but they do try to come in to her bunker in "April Fools Rules".
In "Left in the Dark", her parents tell her not to experiment on her siblings.
They also punish her for causing explosions in/around the household.
In "Future Tense", the parents assigned Lisa to a ceramics studio as her extra curricular activity. She didn't like this at first, but quickly got used to it.
In "The Mad Scientist", the parents are against Lisa going to live at the institute due to her age.
Lisa has a closer appearance to her father, and might have slightly better relationship with him, rather than her mother.
In "Vantastic Voyage", Lynn Sr. made Lisa wear a saliva shield, which she disliked.
In "Health Kicked", Lisa helps Lynn Sr. exercise by teaching him Tai Chi.
In "Making the Grade", it is revealed that she helps him cook dinner.
In "Anti-Social", to help her Dad have fun without the Internet, Lisa spends time with him by building a model molecule.
In "Home of the Fave", he sees her looking unhappy, believes she feels left out, and reads to her. Even though Lisa didn't feel left out and we never find out why she was sad, it did seem to cheer her up.
In "Any Given Sundae", Lynn Sr. dismisses Lisa's suggestion that Lily orchestrated getting her first sundae as silly due to Lily's young age.
In Lisa's Listen Out Loud episode, Lynn Sr. pretends to be British so that he can ask Lisa if he would still be able to buy ice cream sandwiches after purchasing his groceries.
Lisa views attachment to pets as irrational and, like her family, isn't above experimenting on them. Despite this, she actually loves the pets and doesn't want anything too bad to happen to them.
Lisa and Cliff get along OK.
In "Pets Peeved", she says to him, "How's my felis cattus?".
In "Garage Banned", Luan uses Cliff in a joke to Lisa about giving Lucy a CAT scan.
Lisa seems to get along well with Clyde most of the time. She treats him similarly to how she treats her sisters. Lisa has used Clyde as a test subject and called him a fool in the past, but seems to like him nonetheless. Clyde doesn't mind being used as part of her experiments.
In "Overnight Success", Lisa tries to experiment on Clyde.
In "Attention Deficit", Lisa stays over with Clyde and his dads and wants to stay the night there, but Clyde's dads send her and the rest of the sisters home.
In "Baby Steps", he ties her shoelaces and tells him he is a lifesaver. However, everything turned out to be Lincoln's plot.
In "Making the Grade", Lisa takes his seat next to Lincoln, leaving him heartbroken that he couldn't sit next to his best friend anymore.
In Dairyland Amoosement Park (game), they ride the Teacups ride together.
David helps Lisa out by cleaning her glasses from a chemical explosions's soot. Lisa, thinking he sent her a love letter, watched him as he slept and offered him a pig's still beating heart. After that, she slips a love note under his microscope, much to his joy.
In "Friendzy", Lisa invited him over to get special privileges.
Darcy is Lisa's classmate in Ms. Shrinivas's kindergarten class and her first friend.
Lisa chooses Darcy to be her new friend after Ms. Shrinivas tells her that she needs to make a human friend in order to bring up her grade in social skills. At first Lisa only acts like a friend just to boost her mark, and once she gets an "A" she tells Darcy the truth, hurting Darcy's feelings. Ms. Shrinivas revokes Lisa's "A" and gives her a time out for how she treated Darcy. During Lisa's time out, Darcy comes by and gives Lisa a cookie out of sympathy, and Lisa, realizing the benefit of having friends, offers Darcy half the cookie and invites Darcy to join her, rekindling their friendship.
In "Friendzy", Lisa invited Darcy over to get special privileges.
In "Racing Hearts", they were partners for the Astonishing Quest. During the laser tag challenge, she and Darcy got hit as Lisa told her not to wear white.