Late at night in a big city, Ace Savvy and One-Eyed Jack are trapped by the diabolical Wild Card Willy. As the two superheroes are being lowered into a shark tank, Ace Savvy announces that he has back up. After tossing a deck of cards onto the floor, a van full of superheroines arrive to save Ace Savvy and One-Eyed Jack, quickly take down Wild Card Willy and his goons.
It turns out that Lincoln and Clyde have just made a comic book based on Ace Savvy, which they show to Rusty, Liam, and Jordan. When they're asked where he got the idea to use the superheroines, Lincoln says he based them on his sisters, since they always have his back (except for Lola). The boys say that they are submitting it to the creator, Bill Buck, because if they win, they get to meet the creator of Ace Savvy in person. While everyone is confident that Lincoln and Clyde will win, Principal Huggins arrives, and warns the two that school is a place for learning, not for doodling. Because of this, he confiscates the boys' comic, and refuses to give it back to them until 5PM, not before giving them detention. However, the post office closes at 4PM.
To make sure Lincoln and Clyde don't try to get their comic book back, Principal Huggins has the boys clean up chalkboard erasers in a classroom. Lincoln suggests that they escape, but Principal Huggins has the door locked and the window welded shut. Just as Lincoln suggests another plan to escape with pencils, the door suddenly unlocks. It turns out Lola used her tiara to unlock the door (as she said their idea wasn't any good). She, along with Lana, are setting them free because they won't let the principal take away their chances of winning the competition and making them famous.
Upon arriving to the principal's office, an assistant named Cheryl, informs Principal Huggins that there are bats loose in the gym (courtesy of Lucy), prompting him to exit his office and take care of the situation. However, now they need to think of a way to get rid of Cheryl. Lisa arrives, telling Cheryl that she assessed the school's budget, and explains that it has some major flaws. Despite doubting her, Cheryl is proven wrong when Lisa presents her with all of the information she went through. With Cheryl distracted, Lincoln and Clyde dart into Principal Huggins' office to find their comic. However, the moment they find it, Principal Huggins arrives back to get his stuff before heading off, including the satchel the comic was in.
Lincoln, Clyde, Lana, Lola, and Lisa burst out of the school, and notice that Principal Huggins is getting away. At that moment, the van arrives, carrying the other sisters, sans Lily (Lucy was somehow in the van already). Realizing the boys' chances of winning are in jeopardy, Lori immediately guns it and Luna plays some action music as they give chase. Lynn tries to catch the comic with her boomerang, but only succeeds in getting a raccoon. After a brief moment of tension with Scoots at a crosswalk, Luan grabs a banana Lola was eating, and uses Lana's slingshot to fling the banana peel in front of Principal Huggins. His cart hits the peel, causing him to swerve out of control, and in the process, lose the comic. Lincoln and Clyde get the comic back, and are prepared to head to the post office, when suddenly, the engine breaks down. However, Leni (along with a farmer) are able to get the van to the post office by being towed there (by using Leni's sash). Upon arriving, Lincoln and Clyde discover that Principal Huggins is submitting his own comic. Caught in the act, Principal Huggins tries to escape, but trips on Scoots. Lincoln and Clyde realize that Principal Huggins deliberately took their comic away just so he can eliminate them from the competition.
Principal Huggins, admitting defeat, tells the boys that when he was young, he didn't have many friends, but he had Ace Savvy. Because he had Ace Savvy, it helped him cope with his lonely childhood, and wanted to win the competition to meet Bill Buck to thank him for creating Ace Savvy. Lincoln and Clyde, realizing that this means a lot to Principal Huggins, decide to make one last altercation to their comic. With the help of Principal Huggins to buy them enough time, Lincoln is able to rewrite the ending to his comic and submit it with Principal Huggins credited as a co-writer.
Ace Savvy and One-Eyed Jack are about to arrest Wild Card Willy, when Wild Card Willy admits that the only card game he knew was Solitaire. Having a change of heart, Ace Savvy and One-Eyed Jack decide to let Wild Card Willy assist them in taking down another enemy named The Old Maid (portrayed by Scoots).
Bill Buck, reading the comic in his studio, applauds the boys for making a comic that has a lot of heart. When the boys say they did this because they wanted their principal to meet him in person, Principal Huggins, at a loss for words, passes out from over-excitement. Suddenly, the sisters arrive, and begin to surround Bill to talk about the comic, causing Bill to remark "This is kind of a... full house!"