Seeing his sisters squabble with their roommates, Lincoln suggests a roommate shuffle, based on a compatibility test he and Clyde took.
Lincoln is in the living room, watching a baking show called Dessert Storm. However, before Lincoln can see which of the two contestants is the winner, Lola pauses the video, and begins complaining that Lana is ruining all of her dolls. Lincoln attempts to watch his show again, but this time, Lynn arrives, and complains that one of Lucy's bats bit her on the arm, and now has a taste for her blood. As Lynn runs away from the bat that bit her, Lincoln once again tries to see who the winner will be, but this time, Leni arrives, and complains how Lori's hair ruined one of her hairpins. Leni notices the show Lincoln is watching, and accidentally announces the winner, much to Lincoln's despair.
Lincoln enters his room, and gets a video call from Clyde on his laptop. As they begin talking, Clyde overhears a loud ruckus from Lincoln's side of the call, and Lincoln informs him that the roommates are squabbling with each other. As Clyde acknowledges the fact that he and Lincoln are great for each other due to getting the same score on a compatibility test, Lincoln realizes that if he makes his sisters take a compatibility test, he might be able to figure out which roommate is best suited for who. Lincoln proposes his idea to his sisters, and they immediately go along with it, not wanting to spend another moment with their old roommates. After one hour of taking the test, Lincoln has the results:
Lana with Lynn due to their rugged personalities.
Luna with Lisa due to their explosive personalities.
Lola with Lucy due to their flare for the dramatic.
Luan with Leni due to their shared love of laughter.
Lori with Lily because of their respective phones.
That night, Lincoln checks up on his sisters, and discovers that the sisters are getting along with their new roommates. However, just as Lincoln calls up Clyde to inform him that the compatibility test was a success, the roommates are already running into trouble. Lynn is complaining to Lana about her pet rattlesnake resting on her lucky jersey, Lola gave Lucy's bust of Edwin a makeover to bring him to the 21st century much to the latter's dissatisfaction since that is her least favorite century, Lori accidentally stepped on Lily's phone, prompting the latter to post embarrassing photos of her online, Luna's jams have gotten in the way of Lisa's experiments where the D6 note broke her beakers and her glasses, and Leni would annoy Luan by laughing at every little thing she would say, such as having to go to the bathroom. The sisters are quick to chastise Lincoln, since the compatibility test didn't work. Lisa looks over the compatibility test Lincoln gave them, and discovers that it came from one of Lincoln's Ace Savvy comics, meaning that the test only works on fans of Ace Savvy. Because of this, Lisa proposes on using an actual compatibility test.
Lisa unveils a machine that will calculate on which sister works best for the other by using collective data such as report cards, journals, medical records, and DNA samples. After scanning the information, Lisa is given a list on who goes with who:
Lori with Lola because of their authoritarian nature.
Leni with Lynn where they asked Lisa how they are compatible at the same time.
Luna with Lana because of their garage-based hobbies and their respectful axes.
Luan with Lucy due to their shared creativity and their way of befriending inanimate objects.
Lincoln with Lily, leaving Lisa all alone.
Vexed, Lincoln objects to this, saying that he and Lily have nothing in common, and Lisa wants a roommate but she seems to match with no one. This confuses her and as she scratches her head, her hair accidentally falls off, revealing her brain to be a pulsating green, much to the sheer horror and disgust of her siblings.
That night, Lincoln is unable to sleep due to Lily babbling loudly in her sleep and the smell of her diapers contaminating the entire room. Lincoln barges into his room (which Lisa is staying in), and complains that her compatibility test must have some flaws as well. Lisa looks over the information, and discovers that the sisters who are paired have compatibility over 90%, while Lincoln's compatibility with Lily is only a measly 17%. Because of this, Lincoln threatens to make the sisters go back to their original rooms, but as he does so, he sees that the roommates are getting along really well. Luna and Lana get along by playing with both mud and drums, Lynn uses Leni as a weight, causing the latter to use that to decorate the ceiling, Luan and Lucy are getting along playing a friendly game of poker, and Lori and Lola get along bossing others around with their strict behavior. As Lincoln heads back into the room he's staying in, Clyde calls him, and tells him that his sisters are happy with their new roommates, and because of this, he decides to take one for the team by letting them stay that way, and accept the fact that he has to stay with someone he doesn't have a lot of relatability to. Unbeknownst to him, the sisters overhear his conversation, and look at each other with concern.
The next day, Lincoln wakes up, and discovers that he's back in his original room. Just as Lincoln begins to question whether or not he's dreaming, the sisters enter, saying that they overheard his conversation with Clyde last night, and are grateful at the fact that he decided to take one for the team, so they decided to return the favor by going back to their original rooms with their original roommates, saying that they'll try their hardest to correct their behavior. As Lincoln appreciates his sisters for what they did, they all leave, except for Lisa, who informs him that some of her chemicals might still be in his room, and says that if he ever finds one of them, he should let her know. Suddenly, the second Lisa leaves, one of her chemicals blows up in Lincoln's room, covering the entire room in soot, and his hair to fall off, revealing that he now has a pulsating green brain just like Lisa has.
Some of the sisters' squabbles don't make much sense, since they appear to be one-sided. One example of this is when Lynn said that one of Lucy's pet bats bit her on the arm. While this may be a problem for Lynn, it's not a problem for Lucy.
When Lincoln is trying to sleep, his eyes are bloodshot, but when he gets up to see Lisa, they're gone. The same error happened in "The Price of Admission".
Lynn and Lana are shown to be incompatible with each other, even though the two got along fine in "Linc or Swim" and "Suite and Sour", and also despite the fact they're close to each other due to their tomboyish natures.
In the Latin American dub, when Lisa presents Lori and Lola as compatible roommates, she says Lana's name instead of Lola's.
When Lola says that Lana and Lynn carried Lincoln while he sleeps, both seems exhausted, but in "Get the Message", Lucy holds him without any problem. Considering Lucy weaker than Lynn and a little stronger than Lana, they shouldn't have done any effort.
Also, Lynn carried Leni without effort when they shared the room.